Which Lemsip products are NOT suitable for doctor or pharmacist prior to using any of the products. Other NSAIDs including cyclo-oxygenase-2 selective inhibitors: Avoid concomitant use of two or more NSAIDs as this may increase the risk of adverse reactions (see Section 4.4). where can i donate blood if i have hemochromatosis; matt eberflus lions; how to keep birds from perching on window sills; how much does a texas metal car cost; edgerrin james wife; terri apostle married; craigslist oahu pets lost and found; . Don't take Lemsip cold & flu sachets with any other medicines that contain paracetamol or a decongestant. But the color of your vomit tells you a lot about what's going on. Vitamins that are water-soluble dissolve in water so that your body can utilize them. JAMA 255 (1986): 2636-7, 8. You should avoid taking Lemsip cold & flu sachets one hour before or six hours after taking colestyramine. The product should be used with caution in combination with: Anti-coagulants: NSAIDs may enhance the effects of anticoagulants such as warfarin (see Section 4.4). Lemsip sachets do contain sugar however Lemsip capsules are Expert Review Panel", 2. Also, in some cases in Maharashtra, when people eat after taking vaccination on an empty stomach it resulted in acidity, headache and uneasiness. As a general rule, medicines that are supposed to be taken on an empty stomach should be taken about an hour before a meal, or 2 hours after a meal. Ann Emerg Med 26 (1995): 49-53, 34. I've had all three FEC sessions and coped really well and was positive and active. What medications cause liver enzymes to be elevated? Kurtovic J, Riordan SM "Paracetamol-induced hepatotoxicity at recommended dosage." Gastrointestinal: NSAIDs should be given with care to patients with a history of gastrointestinal disease (ulcerative colitis, Crohn's disease) as these conditions may be exacerbated (see Section 4.8). Don't take Lemsip cold & flu sachets if you're taking any of the following medicines, because the combination may increase your blood pressure: If you're taking medicines for high blood pressure you shouldn't take Lemsip cold & flu sachets, because the decongestant may make your blood pressure medicine less effective. overactive thyroid/hyperthyroidism as the active decongestants Don't take Lemsip max flu lemon if you have taken a type of medicine called a monoamine oxidase inhibitor (MAOI) in the last 14 days. People with a tumour of the adrenal gland (phaeochromocytoma). People with a tumour of the adrenal gland (phaeochromocytoma). It generally takes 4 to 5 hours for the stomach to empty after. Severe hypertension may need to be treated with alpha blocking medicinal products such as phentolamine. Add half a cup of hot (not boiling) water and stir to dissolve. This medicine contains less than 1 mmol sodium (23 mg) per 2 tablets, that is to say essentially `sodium-free'. 8. One of their actions is to sensitise nerve endings, so that when that area is stimulated it causes pain (presumably to prevent us from causing further harm to the area). Start typing to retrieve search suggestions. 6 Sometimes fatal, particularly in the elderly. Can I take other medicines with morphine? Not unless your doctor thinks it's essential. Prostaglandins are produced by the body in response to injury and certain diseases. coronary artery disease, cardiac failure, or any other heart Blood 109 (2007): 3608-9, 45. It has given us the most consistent results, as your stomach may be able to process amino acids faster. Save the tomatoes for dinner salad. Johnson GK, Tolman KG "Chronic liver disease and acetaminophen." If ibuprofen is used by a woman attempting to conceive, or during the first and second trimester of pregnancy, the dose should be kept as low and duration of treatment as short as possible. Lancet 342 (1993): 869, 22. Be sure to discuss the best options to lower your risk of GI problems with your doctor first. Please. can i take lemsip on an empty stomach can i take lemsip on an empty stomach. When taken with food, peak levels are observed after 1-2 hours. Within each frequency grouping, adverse events are presented in order of decreasing seriousness. If symptoms persist or worsen, consult your doctor. Kawada A, Hiruma M, Noguchi H, Ishibashi A "Fixed drug eruption induced by acetaminophen in a 12-year-old girl." View Profile View Forum Posts Power Lifter Join Date Oct 2013 Posts 5,665 Supplement Reviews Read All Reviews Source Reviews When taken with food, peak levels are observed after 1-2 hours. If you are looking for a combination product to help with the symptoms of cold and flu, then you could try Lemsip max cold & flu capsules, containing paracetamol and phenylephrine. Other dosage forms: Along with its needed effects, acetaminophen (the active ingredient contained in Lemsip Max) may cause some unwanted effects. 17. aspirin, acetaminophen, ibuprofen, tramadol, cyclobenzaprine, diclofenac, Tylenol, oxycodone, naproxen, Paracetamol. Leave at least four hours between doses and do not take more than 6 tablets in any 24hour period. Lithium: There is evidence for potential increase in plasma levels of lithium. Don't take Lemsip max flu lemon if you have taken a type of medicine called a monoamine oxidase inhibitor (MAOI) in the last 14 days. Lemsip cold & flu sachets should only be used for the short period to relief the symptoms of cold or flu. Tylenol is safer for your stomach than NSAIDs like Advil or Motrin ( ibuprofen ), which can cause stomach bleeding or ulcers. Lemsip Max All Day Cold & Flu Tablets - Summary of Product Characteristics (SmPC) - (emc) Lemsip Max All Day Cold & Flu Tablets Active Ingredient: ibuprofen, phenylephrine hydrochloride Company: Reckitt Benckiser Healthcare (UK) Ltd See contact details ATC code: M01AE51 About Medicine General Sales List In general, acetaminophen (the active ingredient contained in Lemsip Max) is well-tolerated when administered in therapeutic doses. This information is for use by healthcare professionals, RB Consumer Relations, PO Box 4644, SLOUGH, SL1 0NS, UK. People should not take more than one product which contains Respiratory: Bronchospasm may be precipitated in patients suffering from or with a prvious history of bronchial asthma or allergic disease. Note: This document contains side effect information about acetaminophen. Check the ingredients listed in the leaflet provided with the medicine if you know you have specific allergies or intolerances. Yes, you can definitely get a massage! It can actually help you feel better by relieving your symptoms. Ann Allergy 72 (1994): 285, 40. label. It is a recognised decongestant and acts by vasoconstriction to reduce oedema and nasal swelling. age of 12 years old. Singer AJ, Carracio TR, Mofenson HC "The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction." N Engl J Med 303 (1980): 47, 44. See individual packs dehydrated patients or elderly patients with compromised renal function) the co-administration of an ACE inhibitor or Angiotensin II antagonist and agents that inhibit cyclo-oxygenase may result in further deterioration of renal function, including possible acute renal failure, which is usually reversible. There is evidence of an increased risk of haemarthroses and haematoma in HIV(+) haemophiliacs receiving concurrent treatment with zidovudine and ibuprofen. professional.Reckitt Benckiser TAPS NA6601, Always read the label and use only as directed. The antidiabetic medicines exenatide, lixisenatide and liraglutide may slow down the absorption of paracetamol into the bloodstream, so Lemsip max flu lemon might take longer to work if you are using one of these medicines to treat your diabetes. Some Doctors and medical professionals just generally tell everyone to take antibiotics on an empty stomach, mainly because they don't know which ones you need to and which ones you don't, so they play it safe - but that is not "safe" because as someone else said, doxy can burn and damage the esophagus in the long run. Cold and flu remedy contains paracetamol and phenylephrine. Arch Intern Med 145 (1985): 2019-23, 7. Vomiting Nausea Bloating Abdominal pain Loss of appetite It's normal to experience a few side effects when you begin your antibiotics. of Lemsip? There are no specific known reactions between Lemsip and prescribed antibiotics. Treatment should be as clinically appropriate. But massage is good for you - it will reduce stress and increase circulation, so we're all for it! No, DayQuil is not hard on your stomach. overdose of Lemsip? Lemsip, About However, many people have found that if you take your Moringa with food, it will be slightly easier on your stomach. Remember, some medications interact with ibuprofen and health conditions. Lower doses, on the other hand, can cause vomiting. Ann Intern Med 87 (1977): 302-4, 19. 5 The most commonly-observed adverse events are gastrointestinal in nature. This decreases blood flow into the linings of the nose and sinuses, which reduces the feeling of congestion and also reduces the production of mucus. Never take aspirin or Aspirin products and NSAID's on an empty stomach. Generally speaking, it may cause a slight sour stomach, some digestive upset, and a feeling of nausea. breast feeding. This is because your body takes what it needs from water-soluble vitamins and excretes the rest through urine, meaning that it does not require food for absorption. Can you take paracetamol (acetaminophen) with antibiotics? Oct 10, 2012. Exacerbation of asthma is possible in asthmatics. Guess what happens? Of note, single cases of symptoms of aseptic meningitis (such as stiff neck, headache, nausea, vomiting, fever or disorientation) have been observed during treatment with Ibuprofen in patients with existing auto-immune disorders (such as systemic lupus erythematosus and mixed connective tissue disease). Hypersensitivity with urticaria and pruritus2, Severe hypersensitivity reactions, including facial, tongue and throat swelling, dyspnoea, tachycardia, and hypotension (anaphylaxis, angioedema or severe shock) 2, Respiratory, Thoracic and Mediastinal Disorders, Respiratory tract reactivity comprising asthma, bronchospasm or dyspnoea2, Diarrhoea, flatulence, constipation and vomiting, Peptic ulcer, gastrointestinal perforation or gastrointestinal haemorrhage, melaena, haematemesis6. If you're concerned you've taken an overdose of Lemsip you prescribed antibiotics? prescribed antibiotics. Is Tylenol (acetaminophen) an anti-inflammatory drug? You should take it with water 30 minutes before eating breakfast. The risk of hypertension and other cardiovascular side effects may be increased (see section 4.3). All in One Capsules, Lemsip Cough Max for Mucus Cough and Cold Can you have lemsip on an empty stomach? The ibuprofen component of this fixed combination (ibuprofen 200mg plus phenylephrine hydrochloride 5mg) is absorbed faster than standard ibuprofen 200mg tablets, with therapeutic levels being reached in 26.4 minutes (from the fixed combination) as opposed to 55.2 minutes (for standard ibuprofen). You can take these sorts of vitamins as soon . Block R, Jankowski JA, Lacoux P, Pennington CR "Does hypothermia protect against the development of hepatitis in paracetamol overdose?" Brotodihardjo AE, Batey RG, Farrell GC, Byth K "Hepatotoxicity from paracetamol self-poisoning in Western Sydney: a continuing challenge." Experimental data suggest that ibuprofen may competitively inhibit the effect of low dose aspirin (acetylsalicylic acid) on platelet aggregation when they are dosed concomitantly. Take zolmitriptan as soon as the migraine headache develops. Phenylephrine is absorbed from the gastrointestinal tract, but has reduced bioavailability by the oral route due to first-pass metabolism. Methotrexate: There is potential for an increase in plasma methotrexate. Acute generalised exanthematous pustulosis (AGEP) has been reported in relation to ibuprofen-containing products. In limited studies, ibuprofen appears in the breast milk in very low concentrations. You can take the basic lemsip, but not the lemsip max as it has a decongestant in it which is not safe. the contents of the sachets. Impaired female fertility: There is limited evidence that drugs which inhibit cyclo-oxygenase/prostaglandin synthesis may cause impairment of female fertility by an effect on ovulation. Can you have Lemsip on an empty stomach? prescribed antidepressants? even if its taken like it should be - ulcers can still arise. Drinking alcohol with Lemsip max flu lemon is best avoided because the combination of alcohol and paracetamol could increase the risk of side effects on your liver. Occasionally patients develop convulsions. 3. - When you eat, you take your supplements. Water-soluble vitamins ideally dissolve best on an empty stomach. The medication will still be effective and you won't have to worry about it making you feel sick. In general, acetaminophen (the active ingredient contained in Lemsip Max) is well-tolerated when administered in therapeutic doses. Int J Dermatol 35 (1996): 148-9, 42. Ann Intern Med 104 (1986): 399-404, 9. People should also not take more Adults, the elderly and children over 12 years: Two tablets up to 3 times a day. Can you take Lemsip capsules if you have a It retains activity as a nasal decongestant when given orally, the drug distributing through the systemic circulation to the vascular bed of the nasal mucosa. Some pharmacodynamics studies show that when single doses of ibuprofen 400mg were taken within 8 hours before or within 30 minutes after immediate release aspirin (acetylsalicylic acid) (81 mg), a decreased effect of aspirin (acetylsalicylic acid) on the formation of thromboxane or platelet aggregation occurred. Vomiting. Zimmerman HJ, Maddrey WC "Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure." 4 Reply pezzatoluke 2 yr. ago LOL, I meant citric acid ** 4 Hepatology 22 (1995): 767-73, 3. My Best Advice? For more information about the possible side effects of Lemsip max flu lemon, read the information provided with the medicine or talk to your doctor or pharmacist. You can take Delta-8-THC on an empty stomach, but it may not be ideal. Med J Aust 157 (1992): 382-5, 18. 2. The product is contraindicated in combination with: Monoamine Oxidase Inhibitors (MAOIs): Hypertensive interactions occur between sympathomimetic amines such as phenylephrine hydrochloride and monoamine oxidase inhibitors (see section 4.3). potential risk of scalding when using boiling water to mix with Some people may experience stomach ache when taking without food, you can try for yourself and if it does. you. sores, ulcers, or white spots on the lips or in the mouth, swelling, pain, or tenderness in the upper abdomen or stomach area. Help coping with Docetaxel/Taxotere .. [Ref], Common (1% to 10%): Increased aspartate aminotransferase, Rare (less than 0.1%): Increased hepatic transaminases, Frequency not reported: Liver failure[Ref], Very common (10% or more): Nausea (up to 34%), Vomiting (up to 15%), Common (1% to 10%): Abdominal pain, diarrhea, constipation, dyspepsia, enlarged abdomen, Postmarketing reports: Anaphylaxis, hypersensitivity reactions[Ref], Common (1% to 10%): Anemia, postoperative hemorrhage, Very rare (less than 0.01%): Thrombocytopenia, leucopenia, neutropenia[Ref], Rare (less than 0.1%): Serious skin reactions such as acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, Very rare (less than 0.01%): Pemphigoid reaction, pustular rash, Lyell syndrome[Ref], Common (1% to 10%): Dyspnea, abnormal breath sounds, pulmonary edema, hypoxia, pleural effusion, stridor, wheezing, coughing[Ref], Common (1% to 10%): Peripheral edema, hypertension, hypotension, tachycardia, chest pain[Ref], Common (1% to 10%): Hypokalemia, hyperglycemia[Ref], Common (1% to 10%): Muscle spasms, trismus, Common (1% to 10%): Infusion site pain, injection site reactions, Tylenol, Paracetamol, Tylenol Arthritis Pain, Ofirmev, +38 more, 1. The Right Dosage. Thanks for your input, much appreciated. People with asthma should discuss the use of Lemsip with their However, if you feel it working right away (1-2 days) then you could conceivably use it with that 5 on 2 off schedule. However, the safety of pseudoephedrine has not been established and some studies have suggested that use of pseudoephedrine in the first trimester may be associated with defective closure of the abdominal wall (gastroschisis) in the baby. There is no recommended daily dosage of Spirulina. Contraindicated in patients currently receiving or within two weeks of stopping therapy with monoamine oxidase inhibitors (MAOIs). A strip pack consisting of a blister tray of white pigmented 250 m PVC/40 gsm PVDC laminate heat-sealed to lacquered 20 m aluminium foil containing 2, 4 or 8 tablets. Inhibition of prostaglandin synthesis may adversely affect the pregnancy and/or the embryo/foetal development. In view of the lack of data on the use of phenylephrine during lactation, this medicine should not be used during breast feeding. When suggestions are available use up and down arrows to review and ENTER to select. Patients should be adequately hydrated and consideration should be given to monitoring of renal function after initiation of concomitant therapy, and periodically thereafter. michael sandel justice course syllabus. - Yes. Adverse events which have been associated with ibuprofen and phenylephrine hydrochloride are given below, tabulated by system organ class and frequency. ibuprofen-based painkillers? paracetamol at any one time. Recently bought some and have been experiencing vomiting, nausea, diarrhoea (3-4 hours after taking). Lemsip Max All Day Cold & Flu Tablets, or, Lemsip Max All Day Flu Relief Tablets, or. insignia 55-inch fire tv; schnebly hill road status; how can you break a table into two parts; willow tree shepherd and stable animals in box . You can take Tylenol on an empty stomach, but make sure to take it with a full glass of water. There are no specific known reactions between Lemsip and It is also used for its antipyretic effects, helping to reduce fever. The product should be avoided in combination with: Aspirin (acetylsalicylic acid): Concomitant administration of ibuprofen and acetylsalicylic acid is not generally recommended because of the potential of increased adverse effects, unless low-dose aspirin (not above 75 mg daily) has been advised by a doctor (see Section 4.4). Acute renal failure and liver damage may occur. coronary artery disease, cardiac failure, or any other heart Please discuss with a doctor or pharmacist before Select Page. You should leave at least 4 hours between doses of Lemsip. Iron is absorbed the best on an empty stomach. Any other meds and dietary supplements should be taken at least 4 hours away from thyroid meds if at all possible. Why? You should wait at least 2 hours after having these . McJunkin B, Barwick KW, Little WC, Winfield JB "Fatal massive hepatic necrosis following acetaminophen overdose." Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Hum Toxicol 7 (1988): 33-4, 10. 3 Reply nevertricked 2 yr. ago I hope you're not ingesting Nitric Acid. In non-hospital settings, the patient should consult a doctor if symptoms persist or worsen. 4, 6, 8, 10, 12, 14 or 16 tablets). Don't use this medicine for longer than three days without getting medical advice from your doctor or pharmacist. Discuss with your pharmacist or doctor what's This is reversible on withdrawal of treatment. How long does it take for Tylenol to start working? Doan T, Greenberger PA "Nearly fatal episodes of hypotension, flushing, and dyspnea in a 47- year-old woman." Guccione JL, Zemtsov A, Cobos E, Neldner KH "Acquired purpura fulminans induced by alcohol and acetaminophen - successful treatment with heparin and vitamin-k." Arch Dermatol 129 (1993): 1267-9, 47. decongestant, should not be taken by people with a history of Rumore MM, Blaiklock RG "Influence of age-dependent pharmacokinetics and metabolism on acetaminophen hepatotoxicity." These interactions should be considered in patients taking a coxib concomitantly with ACE inhibitors or angiotensin II antagonists. Some Lemsip products contain ibuprofen so always read the Can Lemsip be prepared with cold water? Moringa can be taken on an empty stomach and will allow your moringa to start working much faster than if your stomach was not empty. It's not known if phenylephrine passes into breast milk, or its effect on a nursing infant. We earn a commission for products purchased through some links in this article. Pharmacotherapeutic Group: Anti-inflammatory and anti-rheumatic products, propionic acid derivatives; ATC Code: M01AE51. Paracetamol is thought to relieve pain by reducing the production of prostaglandins in the brain and spinal cord. Shriner K, Goetz MB "Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine." Injection site pain and injection site reaction have been reported with the IV product. MAOIs include the antidepressants phenelzine, tranylcypromine, isocarboxazid and moclobemide, and the anti-Parkinson's medicines selegiline and rasagiline. Clinical studies suggest that use of ibuprofen, particularly at a high dose (2400 mg/day) may be associated with a small increased risk of arterial thrombotic events (for example, myocardial infarction or stroke). Paracetamol is a painkiller that can relieve mild to moderate pain such as headaches, sore throat, sinus pain and aches and pains associated with colds and flu. Most adults can safely take up to 4,000 mg of regular strength Tylenol in a day. Sympathomimetic amines: concomitant use of phenylephrine with other sympathomimetic amines can increase the risk of cardiovascular side effects. 13. . Ask your doctor or pharmacist for further advice. 4 Clinical trial and epidemiological data suggest that use of ibuprofen, particularly at high doses (2400 mg daily) and in long-term treatment, may be associated with a small increased risk of arterial thrombotic events (for example, myocardial infarction or stroke) (see Section 4.4). Patients taking NSAIDs and quinolones may have an increased risk of developing convulsions. It allows continued monitoring of the benefit/risk balance of the medicinal product. Unless you have sensitive bowels, we think the best time to take creatine is on an empty stomach just before or after a resistance training workout. The excretion is rapid and complete via the kidneys. Take multivitamins or prenatal vitamins with a meal or snack containing fat and a glass of water. How long does Percocet stay in your system? Whitcomb DC, Block GD "Association of acetaminopphen hepatotoxicity with fasting and ethanol use." I take supplements after breakfast. Features of severe overdose of phenylephrine include haemodynamic changes and cardiovascular collapse with respiratory depression. JAMA 236 (1976): 1874-5, 20. Can you take Lemsip while breast feeding? Lemsip products not suitable for vegetarians are: Lemsip Max For this reason, Lemsip max flu lemon is best avoided by mothers who are breastfeeding. A swift and successful op was followed by FEC-T chemo. Taking Delta-8-THC with food may result in slower rolling, more consistent effects. In humans ibuprofen reduces inflammatory pain, swellings and fever. What should I do if I suspect I've taken an Netdoctor participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites. Leung R, Plomley R, Czarny D "Paracetamol anaphylaxis." can i take lemsip on an empty stomach. If a dose is missed, skip the missed dose and take the next dose at the regular time. Research suggests that taking THC with food can help increase the amount of THC that is absorbed. Brown G "Acetaminophen-induced hypotension." 03/07/2022 . Bloating. A second serving should be taken with your post-workout meal. Otezla belongs to the class of medicines known as phosphodiesterase 4 (PDE4) inhibitors. Frequencies are defined as: Very common (1/10); Common (1/100 and <1/10); Uncommon (1/1000 and <1/100); Rare (1/10,000 and <1/1000); Very rare (< 1/10,000); Not known (cannot be estimated from the available data). Eur J Clin Pharmacol 38 (1990): 389-90, 37. Medicines and their possible side effects can affect individual people in different ways. Not to be given to children under 12 years. Reduced numbers of white blood cells or platelets in the blood. ingredients and is not recommended. BMJ 306 (1993): 157-8, 23. Zidovudine: Increased risk of haematological toxicity when NSAIDs are given with zidovudine. N Engl J Med 331 (1994): 1311, 29. monoamine-oxidase inhibitor antidepressant (MAOI), overactive thyroid gland (hyperthyroidism). For the relief of symptoms of cold and 'flu with associated congestion, including aches and pains, headache, fever, sore throat, blocked nose and sinuses. Some side effects may not be reported. - Very good. Here are some of the severe and potentially long-term side effects to be aware of when considering or taking propranolol: Hallucinations Cold hands or feet Muscle weakness Muscle cramps Shortness of breath Memory loss Fluid retention Blood sugar changes Insomnia and nightmares Allergic reaction Vomiting Shakiness Weight gain Skin rash Ann Allergy 72 (1994): 285, 41. Maximum plasma concentrations are reached 45 minutes after ingestion if taken on an empty stomach. 14. Take LINZESS on an empty stomach, at least 30 minutes prior to the first meal of the day. Traveler said it best - eat before and then after. best for you. Ask your pharmacist for more advice. Koulouris Z, Tierney MG, Jones G "Metabolic acidosis and coma following a severe acetaminophen overdose." Extras: These options include taking digesive with food, taking a digestive with food, taking a laxative on an empty stomach, or even taking a laxative without food. Hypertension and severe coronary heart disease or cardiovascular disorder (see section 4.4). Created for people with ongoing healthcare needs but benefits everyone. What other medicines contain the same active ingredients? In addition, drinking pickle juice on . During the first and second trimester of pregnancy, ibuprofen should not be given unless clearly necessary. If you're already taking any other medicines, check with your pharmacist before taking Lemsip cold & flu sachets, to make sure that the combination is safe. Adults: Do not use for more than a few days unless advised by a Using paracetamol or paracetamol containing products such as Lemsip cold & flu long-term may potentially increase the anti-blood-clotting effect of warfarin, leading to an increased risk of bleeding. Kalyoncu AF "Acetaminophen hypersensitivity and other analgesics." Yes, you can take Dayquil on an empty stomach. Report a suspected side effect or falsified product to the MHRA Yellow Card scheme. Get immediate medical advice in the event of an overdose with this medicine, even if you feel well, because of the risk of delayed, serious liver damage. The lowest effective dose should be used for the shortest duration necessary to relieve symptoms (see section 4.4). Table Of Contents Is DayQuil hard on your stomach? This product should be discontinued at the first appearance of signs and symptoms of severe skin reactions, such as skin rash, mucosal lesions or any other sign of hypersensitivity. 1. Br J Dermatol 115 (1986): 357-9, 46. J Allergy Clin Immunol 84 (1989): 26-33, 36.
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