Ulbricht, C. (2010). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Preclinical studies suggest that oral comfrey has antiproliferative effects , and a topical formulation showed wound healing properties . View abstract. You should never ingest comfrey by mouth. Bagheri Z, Azizi A, Oshvandi K, Mohammadi Y, Larki-Harchegani A. You and your healthcare provider should weigh the pros and cons and use it only under their supervision. To use on established plants, dilute 1 part comfrey fertilizer in 15 parts water. You may report side effects to FDA at 1-800-FDA-1088. Heat oil in double boiler gently then add beeswax until it melts. We cover all you need to know in this article. Comfrey cream may help treat knee osteoarthritis, according to a Cochrane review of topical herbal therapies. Stop using comfrey and call your healthcare provider at once if you have: liver problems-- nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Newer Post Older . Comfrey root: from tradition to modern clinical trials, Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo-controlled, multicentre trial, Topical herbal therapies for treating osteoarthritis, Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials, Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial. A handbook for practice on a scientific basis. Thus, it is not advised to ingest herbal preparations of comfrey unless guided by an expert pharmacologist and physician. (2001). A member of the borage family, comfrey root, leaves, and stems have an obvious coat of bristly hair. Ther Drug Monit 2001;23:698-708. FDA Advises Dietary Supplement Manufacturers to Remove Comfrey Products From the Market. Other alternative therapies may help to ease the pain. Z Phytotherapie 2000;21:127-134. Using it no more than four to six weeks a year as a general guideline would be best. June 3, 2022 Posted by: Category: Uncategorized; No Comments . This perennial can grow up to 4-feet tall. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. 2017;65(1):363-373. doi:10.1002/hep.28813. MedlinePlus Medical Encyclopedia. Do not take comfrey without medical advice if you are using any of the following medications: This list is not complete. Herbal medicine for low back pain: A Cochrane review. Pharmazie 1995;50:83-98. Kucera, M., Barna, M., Horacek, O., Kalal, J., Kucera, A., and Hladikova, M. Topical symphytum herb concentrate cream against myalgia: a randomized controlled double-blind clinical study. 2 cups organic, unrefined coconut oil Phytomedicine, 14(1), 2-10. https://doi.org/10.1016/j.phymed.2006.11.006, Jedlinszki, N., Balzs, B., Csnyi, E., & Csupor, D. (2017). Comfrey cream contains several active components (substances). Don't use comfrey products if you have or are at risk of having liver disease, cancer, or are taking any medication that affects the liver since it may increase the risk of liver toxicity. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. View abstract. View abstract. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. The Herbal Academy makes neither medical claim, nor intends to diagnose or treat medical conditions. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. 2011;10(3):147-56. (21), 498-507. https://link.springer.com/article/10.1007/s10354-004-0114-8, Natural Medicines (2020). Turley, A. J. and Muir, D. F. ECG for physicians: a potentially fatal case of mistaken identity. We're proud to make a difference, and you can to. Combination of comfrey root extract plus methyl nicotinate in patients with conditions of acute upper or low back pain: a multicentre randomised controlled trial. To make this recipe, first, you must prepare the comfrey root tincture. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. This leads to cirrhosis and eventually liver failure. Allow the oil mixture to cool until it reaches room temperature, which could take 8-12 hours. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: Results of a double-blind, randomised, placebo controlled, multicentre trial. Copyright Holland & Barrett Retail Limited, 2022. 12 drops black pepper (Piper nigrum) essential oil For one of these studies, the average time participants had experienced knee pain and stiffness leading up to the study was six and a half years! Arzneimittelforschung, 62(06), 285-289. https://doi.org/10.1007/s10354-007-0474-y, Giannetti, B. M., Staiger, C., Bulitta, M., & Predel, H. G. (2010). Satisfaction. View abstract. Need some help with an order or want to speak to a member of our Customer Services team? Although topical comfrey has been used for this indication, there's little evidence that it helps and can pose a big risk for nursing babies. Potters Herbal Comfrey Oil is a soothing aromatic herbal massage oil. Some of these components are thought to speed up wound healing by stimulating new cell growth. Join rewards for life today and we'll give you 300 points worth 3.00. Call your doctor for medical advice about side effects. 2012;20(11):1209-16. doi:10.1016/j.joca.2012.07.019, Zago LR, Prado K, Benedito VL, Pereira MM. Add comfy to Vaseline . In a randomized, controlled, double-blind study with 203 patients, applications of a 10% comfrey cream were well tolerated, reduced swelling and pain, and improved mobility (Kucera et al., 2004). This comfrey cream recipe works great for local areas that have mild bruising or soft tissue pain. Set aside cup for the cream recipe and store the rest in a glass jar. The first European settlers of America considered comfrey so indispensable, they carried it on their journey across the Atlantic in the 1600s.2. In a randomized, double-blind, placebo-controlled trial, 220 patients with knee osteoarthritis used either a commercial topical comfrey root extract or a placebo. And topical capsaicin cream may help to relieve pain temporarily. Other prescription medicines that may harm the liver include: Some supplements may also harm the liver, including: It is essential to carefully read a supplement's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Bleakley, C. M., McDonough, S. M., and MacAuley, D. C. Some conservative strategies are effective when added to controlled mobilisation with external support after acute ankle sprain: a systematic review. Registered office: Samuel Ryder House, Barling Way, Nuneaton, Warwickshire CV10 7RH. Ask your doctor if you have any questions. Efficacy and tolerance of a comfrey root extract (Extr. Natural Standard. Vickers AJ, Vertosick EA, Lewith G, et al. As we are constantly reviewing and developing our products to meet our consumer needs, consumers, particularly those that suffer from allergies and intolerances, should always check product labelling, warnings, and directions provided with the product that is delivered, prior to use or consumption. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. Commercial comfrey sale and distribution is restricted in Germany and Canada because of its substantial toxicity. 2021;83:e249209. We cover all you need to know in this article. Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: Results of a randomized controlled clinical double-blind study. Facebook; Twitter; Pinterest; Related Posts. Frost R, Macpherson H, O'meara S. A critical scoping review of external uses of comfrey (Symphytum spp.). View abstract. Mosby Elsevier. While there can be a variety of causes for back pain, these small studies offer hopeful results that comfrey root may offer potential analgesic and anti-inflammatory benefits. What Happens If I Use Too Much Comfrey Cream? It also covers side effects, interactions, and what to look for. View abstract. Tolerability and effectiveness of an antitrauma cream with comfrey herb extract in pediatric use with application on intact and on broken skin. Nutrition C for FS and A. After 7 years in this role and a further year working as a drug safety officer in the pharmaceutical industry, Bhupesh joined Holland &Barrett as a Senior Regulatory Affairs Associate in 2019. Whether youre familiar with it or not, this unusual herbal remedy is definitely worth knowing more about. Double boiler Comfrey contains chemicals that cause serious liver damage when taken by mouth. One study followed 142 patients with ankle sprains. View abstract. HOLLAND & BARRETT PRO VITAMIN E DAY CREAM 50ML This Vitamin E day cream works with your skin daily to hydrate and protect your skin. Comfrey. Comfrey has been used medicinally for at least 2000 years for various conditions, including bone fractures, ulcers, and gout. A review of 26 clinical trials concluded that mild skin reactions were the most common side effects of comfrey creams used in the studies. Company number 02758955 Registered VAT number 211727395. (2018). Grube, B., Grnwald, J., Krug, L., & Staiger, C. (2007). Using a combination product makes it challenging to know how much of the beneficial effect came from comfrey alone. Which part of the comfrey plant has the lowest level of pyrrolizidine alkaloids (PAs)? Comfrey cream combines ingredients like oils or water and glyceryl stearate with Symphytum officinale (comfrey) extracts. The study involved 43 patients with knee osteoarthritis and a six-week treatment period. Studies in humans are very limited. Comfrey can kill. The use of babosa (Aloe vera) in treating burns: a literature review. In a small study with 30 subjects, lower back pain from exercise was reduced with an ointment containing comfrey. Efficacy of a comfrey root (Symphyti offic. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. When buying commercial brands, seek those that have had the pyrrolizidine alkaloids removed, if possible. Herbal drugs and phytopharmaceuticals. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. 2004;154(21-22):498-507. Undergoingmassage or taking up yoga may help alleviate pain and help people with back or joint problems function more easily. Koll, R., Buhr, M., Dieter, R., Pabst, H., Predel, H. G., Petrowicz, O., & Staiger, C. (2004). Latest: Senior Software Engineer - Front End Senior Software Engineer Senior Product Manager - Basket, Checkout and Payments UX Designer - Instore Tech. She is passionate about providing evidence-based recommendations that make health decisions easier and improve lives. Comfrey cream All Technology Jobs. To make the cream, combine sunflower oil, safflower oil, coconut oil, and cocoa butter in a double-boiler over low heat until completely melted. Beth Thomas, PharmD, is a clinical pharmacist and founder of BMT Consulting Services, LLC. When harvesting comfrey or buying from a non-commercial supplier, note that there is variety within the species. Make sure to always buy comfrey. 2013;27(6):811-7. 4-4-2009;139(13-14):210-211. Select a condition to view a list of vitamins. Kuera, M., Barna, M., Horek, O., Kovrikov, J., & Kuera, A. 2 Comfrey cream contains several active components (substances). about an hour two nites. Buy 1 get 1 Half Price on Vitamins & Supplements, Popular Vitamins & Supplements Subscriptions, Buy 1 get 1 Half Price gut health supplements, Guide to sleeping better natural sleeping remedies, Living in the now, gut health & mental wellbeing, The thing that makes you different makes you special, Bhupesh Panchal, Senior Regulatory Affairs Associate, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908267/, http://www.missouribotanicalgarden.org/PlantFinder/PlantFinderDetails.aspx, http://www.sciencedirect.com/science/article/pii/S0965229913001672, http://www.ncbi.nlm.nih.gov/pubmed/22887778, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363250/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631335/, https://pubmed.ncbi.nlm.nih.gov/22887778/, https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-symphytum-officinale-l-radix_en.pdf, http://pennstatehershey.adam.com/content.aspx?productid=107&pid=33&gid=000234. Be sure to use comfrey root from a reputable source that has properly identified the species. Grube, B., Grunwald, J., Krug, L., and Staiger, C. Efficacy of a comfrey root (Symphyti offic. Topical preparations of comfrey are generally safe provided they are not applied excessively or to an open wound. Nat Prod Res 2018;32(5):605-9. doi: 10.1080/14786419.2017.1326492. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Arzneimittelforschung. BMJ Case Rep. 2016. Phytother.Res 2012;26(10):1441-1448. Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis. Some drugs increase how quickly the liver changes and breaks down comfrey. NIH Office of Dietary Supplements. The recipe makes about 5 cups of whipped creamy lotion. Published 2021 Sep 20. doi:10.1590/1519-6984.249209, Frost R, MacPherson H, O'Meara S. A critical scoping review of external uses of comfrey (Symphytum spp.). Regul Toxicol Pharmacol. Effects of Symphytum ointment on muscular symptoms and functional locomotor disturbances. Comfrey might harm the liver. Symphytum species: A comprehensive review on chemical composition, food applications and phytopharmacology. Comfrey is generally considered unsafe, with numerous toxicological effects in animals and humans. The leaves and stems of comfrey contain pyrrolizidine alkaloids that can cause toxic damage if ingested in excess (Ulbricht, 2010). Comfrey is often sold as an herbal supplement. These side effects may be common or severe. Aust.Fam.Physician 2008;37(4):235-236. 2758955. Influence of moderate physical exertion on subacute low back pain, after Symphytum officinale ointment treatment. Registered office: Samuel Ryder House, Barling Way, Eliot Park, Nuneaton, CV10 7RH, UK. Although it has historically been used on open wounds, it is now not advised related to the toxic pyrrolizidine alkaloids that can absorb more readily into the body through an open wound. Public Health Nutr 2000;3:501-8. Phytother Res. Rad. Can a comfrey (Symphytum officianale) root extraction help ease aching joints and muscles? 2017;83:1-4. Influence of moderate physical exertion on subacute low back pain, after Symphytum officinale ointment treatment. J Chiropr Med. (2013). Readers must do their own research concerning the safety and usage of any herbs or supplements. (2004). Comfrey (Symphytum officinale) is a plant with yellow or purple flowers found in Europe, Asia, and North America. . The ointment has a very mild herbal fragrance and is soothing on application. This is not a complete list of side effects and others may occur. We go to great efforts to ensure that the information on this page is accurate at the time that the page was last edited. In Western Europe, comfrey has been used topically for treating inflammatory disorders such as arthritis, gout, and thrombophlebitis, and internally for treating diarrhea. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo-controlled, multicentre trial. For External Use only Do not use if you are sensitive to any of the ingredients. Written by Cerner Multum. Phytomedicine, 11(6), 470-477. https://doi.org/10.1016/j.phymed.2004.02.001, Kucera, A., Barna, M., Holcova, S., Horacek, O., Hladikov, M., & Ottillinger, B. All rights reserved. Koll, R., Buhr, M., Dieter, R., Pabst, H., Predel, H. G., Petrowicz, O., & Staiger, C. (2004). Registered in England: company no. J Pharm.Belg. View abstract. We currently have no information for COMFREY overview. Discontinue use if a rash appears. This is not recommended due to the presence of chemicals that can cause organ damage and cancer. It's typically only used in small amounts for a very short period. Pyrrolizidine poisoning. Comfrey is a plant also known as Ass Ear, Black Root, Blackwort, Bruisewort, Consolidae Radix, Consound, Consoude, Consuelda, Gum Plant, Healing Herb, Herbe aux Charpentiers, Herbe la Coupure, Knitback, Knitbone, Langue-de-Vache, Oreille d'ne, Salsify, Slippery Root, Symphytum officinale, or Wallwort. Contact your doctor or pharmacist if you have any questions before use. Heard about essential oils but not quite sure about what they can do for you? The internal or extensive topical use of comfrey cannot be recommended because of numerous reports of liver damage. Barthomeuf, C. M., Debiton, E., Barbakadze, V. V., and Kemertelidze, E. P. Evaluation of the dietetic and therapeutic potential of a high molecular weight hydroxycinnamate-derived polymer from Symphytum asperum Lepech. Comfrey is not recommended for children under three years old, as it's not been studied in that population. 2019;24(12):2272. doi:10.3390/molecules24122272, Staiger, Christine. For this reason, some topical products are advertised as made from comfrey leaves, but it's safest to choose a PA-free product. A multi-center, randomized, double-blind, controlled clinical trial was conducted with 161 patients having acute lower back pain. Comfrey's original name, knitbone, derives from the external use of poultices of its leaves and roots to heal burns, sprains, swelling, and bruises. Hybrids and other species may have a similar appearance but could have significantly different amounts of the toxic pyrrolizidine alkaloids (Kucera et al., 2018). Efficacy of a comfrey root (Symphyti offic. root extraction help ease aching joints and muscles? To Use. Comfrey also is known as Russian comfrey, knitbone, radix consolidate, bruisewort, blackwort, and slippery root. An ankle sprain can come out of nowhere and cause a lot of pain, limitations, and regret until it is healed. In a randomized multicenter study with 164 ankle sprain patients, swelling and pain were improved more successfully using a comfrey root extract compared to a diclofenac gel (Predel et al., 2005).
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