molecular mechanisms by which the non-structural protein The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. The vaccine has a limited number of spike proteins, and since its not part of a virus it cannot reproduce. The information is. New research: Besides initiating infection, coronavirus spike protein has key role in illness The paper also finds that Covid-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system (comprising the blood vessels) on a cellular level. There is no evidence that the spike protein in vaccines is toxic or that it lingers at any toxic level in the body after vaccination, an FDA spokesperson told us in an email. Shyy, 31 March 2021, Circulation Research.DOI: 10.1161/CIRCRESAHA.121.318902. . Instead, each carries molecular instructions, called messenger RNA (mRNA), that tell our bodies how to fight off the virus. Germany has lifted all Covid restrictions for entry into the country. To view the purposes they believe they have legitimate interest for, or to object to this data processing use the vendor list link below. shows that SARS-CoV-2's "distinctive 'spike' protein . If they are so safe, surely companies should have confidence in their products? Looking into the adverse event database in the United States, we have found evidence of suckling infants experiencing bleeding disorders in the gastrointestinal tract.. Scientists have known for a while that SARS-CoV-2 's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. 27 May 2021. Is it a safe assumption that it stays in the shoulder muscle? Yes, thats why they induce vascular effects in some cases. This frees the (likely many) whole and partial spike proteins inside the cell into the blood. COVID-19 vaccine for children. Statement, Canadian Paediatric Society. The commonality between them is that they all have vascular underpinnings.. Yes. The, , called 2P, as in two proline molecules, is, No Evidence Vaccine-Generated Spike Protein Is Harmful, prepared in response to the attention brought by the interview, Bridle says the Canadian government should be called upon to immediately halt the mass vaccination program of children and adolescents. He says there is no immediate threat of severe COVID-19 in the majority of Canadian children and adolescents, and that more safety and efficacy data is needed for the use of experimental vaccines., the use of the Pfizer/BioNTech COVID-19 vaccine in children 12 to 15, following authorization of the vaccine in youth 16 years old and older in December. Their pipeline And look into the heavens and see the sun and all the stars in Heaven. Lies tall mountains in which hidden within them lies a sea of water. In contrast, middle-aged adults with co-morbid conditions who are vaccinated may be more likely to experience delayed adverse events (on the whole). See: https://www.jpost.com/health-science/could-an-mrna-vaccine-be-dangerous-in-the-long-term-649253, If these spike proteins are expressed in endothelial cells, which are found in the vascular system, brain and other organs, the protein can presumably damage that tissue in a way that may not be readily apparent. Episode 41. It is a beautiful forest with trees so tall and wide. Even if its turns out to be true that mRna spike proteins can harm your cells. All nice, but the spike proteins are already IN the cells since they are produced there and the study says: [] but this is the first study to show that the damage occurs when CELLS are exposed to the spike protein on its own. overcome intractable clinical challenges, not just of SARS CoV- Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together. DOI: , a structural biologist at the University of Texas at Austin who has been studying spike proteins in other coronaviruses for. As mentioned, the spike protein is itself a pathogen. No, so learn a lesson from a dummy, Dont trust pharmaceuticals and governmental joint campaigns! Theyve already poisoned the water, the food and the air, not to mention taxing you for everything so, yeah, another vaccine campaign because they just care so much about the cowswake up you fools! 10 June 2021. But, he said, there is one key difference, in that the spikes encoded by the vaccines contain 2 amino acid changes that help stabilize the spike in its initial conformation and help prevent the spike from undergoing a conformational change that is required to facilitate membrane fusion.. Neither vaccine contains any real virus. Email sent to FactCheck.org. Anyone can submit a report of an event to VAERS, even if its not clear that a vaccine caused the problem, and all of the notifications are accepted without determining if the event was caused by a vaccine. Researchers detected levels of SARS-CoV-2 protein as early as one day after the first injection in 11 of the 13 participants. Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own. 2021 Oct 13;2021.10.12.464152. doi: 10.1101/2021.10.12.464152. Copyright 1998 - 2023 SciTechDaily. Yes, and thats why it can make you a little ill. . Clinical Infectious Diseases. surfactant in COVID-19 patients. I think, adverse effects of the vaccine happen more often if the needle hits near a bigger blood vessel in the muscle. Accessed 29 June 2021. The spike protein gets into the blood, circulates through the blood in individuals over several days post vaccination, it accumulates in a number of tissues such as the spleen, the bone marrow, the liver, the adrenal glands and in quite high concentrations, in the ovaries, he said. Which is totally different from the wild version. Your comment is exactly the type of thing that fails the smell test. However, this is theoretical; the exact mechanism by which COVID-19 infection leads to cardiovascular symptoms is still unclear., Susan Weiss, a coronavirus researcher and professor of microbiology at the Perelman School of Medicine at the University of Pennsylvania, says there is not much virus in the blood following infection with SARS2., I am quite confident that the spike protein is not a toxin, she told FactCheck.org in an email. If a burgler, theoretically, is born inside your house and cannot get out alive and is killed by the residents, there is no damage and no damage in the future at other houses. following SARS-CoV-2 infection as a way to understand I agree that if the mRNA vaccines themselves stimulate the human bodys cells to produce spike proteins, shouldnt there be some concern that by this process the mRNA vaccines could ultimately cause the same vascular damage? Scientific discovery at the Salk Institute is made possible through your annual contributions. Reading these comments Jonathan is wrong. The research findings will impact predictions of COVID patients disease course when they check in to the hospital and finding the right treatment to accelerate recovery. Email sent to FactCheck.org. Centers for Disease Control and Prevention. 2. The mRNA vaccination process hijacks the cell to encode these proteins so were not talking a limited number taken up by the vaccine itself after which no more are produced by the body. No.I also got a history of rare autoimmune disease involving the blood vessels.The question is, do these spike proteins stay in the cells long enough to produce any damage ? The study, in which researchers administered a pseudovirus to hamsters, found the spike protein alone can damage vascular endothelial cells. But as the authors mention, the use of a pseudovirus is a limitation and findings need to be confirmed with the SARS-CoV-2 virus in the future. Email sent to FactCheck.org. It was as he saw as if someone sliced all the way to the middle. The point of the article is that the spike protein is dangerous, so if the vaccine is producing spike proteins, its quite a leap in logic to say that the vaccine is safe (whatever definition that is today). Multiple vaccines are now available to help curb the threat of COVID-19, caused by the SARS-CoV-2 virus. . synthetic virology and chemical biology platforms, to create That if one drink from it ! Having said that, a more complete answer would depend on the age and health status of the vaccinated individual. MYTH: The COVID-19 vaccine can affect women's fertility. 17 June 2021. 21 . Other immune cells will be activated that can seek out and destroy future coronavirus-infected cells displaying the spike. But since its not part of a virus, it cannot replicate. The Salk Institute embodies Jonas Salks mission to dare to make dreams into reality. We thus hypothesised that SARS-CoV-2 could use the ACE2 receptor to infect a range of nonhuman, non-bat hosts. No vaccine is perfectly safe. It is a calculated risk. The miscegenation seems to be the common factor for the number of new variants from South Africa, Brazil, United Kingdom and the United States. An analysis of blood plasma samples from people who recovered from SARS-CoV-2 infections shows that most of the antibodies circulating in the blood -- on average, about 84% -- target areas of the viral spike protein outside the receptor binding domain (RBD, green), including the N-terminal Domain (NTD, blue) and the S2 subunit (red, yellow). I find this very concerning and I already got my first shot. 18 June 2021. The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xian Jiaotong University; and Xian Jiaotong University. Accessed 29 June 2021. The, unpublished study found antibodies in the breast milk from all of the workers andminimal amounts of vaccine mRNA., document, instead saying that detection of the mRNA was downplayed., is designed to detect potential problems thats why its there but it does not show whether the vaccines. If you would like to change your settings or withdraw consent at any time, the link to do so is in our privacy policy accessible from our home page.. (a pretty tall order) There is not enough of the viral matter in the vaccine to do significant harm without replication, which it cannot do. Copyright 2023 Salk Institute for Biological Studies. So by vaccinating people we are inadvertently inoculating them with a toxin., , Bridles research focuses on biotherapies for the treatment of cancers and the way organisms respond to viruses. A post widely shared on social media claims a viral immunologist said COVID-19 vaccines' spike protein means people are being inoculated "with a toxin." Experts say there is no evidence that the . And since elderly people are at increased risk of COVID-19 complications, it makes more sense for them to be vaccinated than not. in the lungs that allows us to breathe. 31 Mar 2021. This binding disrupted ACE2s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented. I dont know if this should worry me more or the same (?). Fact check: COVID-19 vaccines dont produce dangerous toxins. USA TODAY. Scientists have known for a while that SARS-CoV-2s distinctive spike proteins help the virus infect its host by latching on to healthy cells. Jason McLellan, a structural biologist at the University of Texas at Austin who has been studying spike proteins in other coronaviruses for years and whose work was fundamental for the development of COVID-19 vaccines, said Bridles statements are not correct. 31 Mar 2021. In addition to Salks ongoing collaborative research areas that explore fundamental biological questions relevant to COVID-19, several new, coronavirus-specific projects have recently launched. Anyone can submit a report to VAERS for any health problem that occurs after an immunization. Vaccines, pregnancy, menstruation, lactation and fertility. Science in 5. If successful, this approach could be The spike protein, particularly the RBD, is therefore the main antigenic target for vaccine formulation. That being said, most vaccines are essential for health but with these covid vaccines there has been a suspension of scepticism and government and corporate coercion that is extremely alarming. Accessed 29 June 2021. Nor is it known if one can have no visible symptoms but still have blood related disease that is not visible, or perhaps is not recognized for years. Kaech It also means that while naturally acquired immunity from the infection of SARS COv 2 will have targets from all different parts of the virus, the antibodies produced by the vaccine will only be active for small fragments of the transfigured spike protein induced by the vaccine mRNA. Its internationally renowned and award-winning scientists explore the very foundations of life, seeking new understandings in neuroscience, genetics, immunology, plant biology and more. It is not a toxin, McLellan told us in an email. therapies that express synthetic nanoparticles that seek, Low, Jia Ming, et al. Theres been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. COVID-19 Vaccine Research at U of G Awarded Provincial Funding. Ontario Veterinary College website. So the spike proteins dont need to exit the cells and they dont need to bind to new cells. Like. Pfaeffle, Veronika. The, recommends offering the vaccine to all children and adolescents 12 years of age and older as soon as vaccine supply permits., [T]he spike protein from SARS-CoV-2 might be responsible for at least some of the damage that occurs in severe cases of COVID-19, he says, citing a, , a coronavirus researcher and professor of microbiology at the Perelman School of Medicine at the University of Pennsylvania, says there is not much virus in the blood following infection with SARS2., Study on Vaccine Transfer into Breast Milk Distorted, from Singapore that tested milk samples from 10 lactating health care workers after they were immunized with the Pfizer/BioNTech vaccine. 30 Mar 2021. So by vaccinating people we are inadvertently inoculating them with a toxin.. You dumb asses also watched too much resident evil and think thats actual science and it shows. They travel extensively through the lymph system and a large number end up in the spleen. Theunpublished study found antibodies in the breast milk from all of the workers andminimal amounts of vaccine mRNA.. 21 May 2021. While previously working on a vaccine for MERS, a disease caused by another coronavirus, McLellan and others, that by adding two proline molecules to the spike protein, they could lock it into its pre-fusion state, triggering a more effective immune response and preventing cell entry. development of COVID-19. . Statement, Canadian Paediatric Society. We thought the spike protein was a great target antigen, we never knew the spike protein itself was a toxin and was a pathogenic protein. I have not seen any data to support what Bridle claims., Bridle, who in the radio show said hes very much pro-vaccine, says his claims are completely backed up by peer-reviewed scientific publications in well-known and well-respected scientific journals.. Salk researchers collaborated with scientists at the University of California San Diego on the paper, including co-first author Jiao Zhang and co-senior author John Shyy, among others. The COVID-19 vaccine argument thus far has been one-size-fits all: COVID-19 vaccinations are harmful (antivaxxers) vs. helpful (the majority). who would not be expected to be at high risk from COVID-19 itself. Other authors on the study are Yuyang Lei and Zu-Yi Yuan of Jiaotong University in Xian, China; Cara R. Schiavon, Leonardo Andrade, and Gerald S. Shadel of Salk; Ming He, Hui Shen, Yichi Zhang, Yoshitake Cho, Mark Hepokoski, Jason X.-J. This process ultimately Word of caution re long term safety and giving the vax to young people The PAH survival is 3 years.Im one of those skeptical regarding the vaccines, yet I took the first dose of Pfizer. Ontario Veterinary College website. A lot of people think of it as a respiratory disease, but its really a vascular disease, says Assistant Research Professor Uri Manor, who is co-senior author of the study. . Updated 29 June 2021. With mRNA vaccine technology the spike protein is made inside the cellular machinery, but it goes on to be destroyed once it is made inside the cells and CAN NOT EXIT the Cell intact. Prompting an Immune Response Anyway after drinking this water.He got a different blood type than anyone on earth. In response we got an automatic email reply saying he cannot respond because his workload has become challenging to manage after the radio interview, which led to vicious attacks by some., In two documents prepared in response to the attention brought by the interview, Bridle says the Canadian government should be called upon to immediately halt the mass vaccination program of children and adolescents. He says there is no immediate threat of severe COVID-19 in the majority of Canadian children and adolescents, and that more safety and efficacy data is needed for the use of experimental vaccines., In May, Canada authorized the use of the Pfizer/BioNTech COVID-19 vaccine in children 12 to 15, following authorization of the vaccine in youth 16 years old and older in December. 12 June 2021. Why cant people sue pharmaceutical companies if they have disabling reactions or their family members die from it? Email sent to FactCheck.org. And he thought it was glass laying down on the ground. This suggests a successful immune response doesn't concentrate on the RBD. Ghazvini, Keanna. Interview, Dr. Paul Offit, director of the Vaccine Education Center and an . Reuters Fact Check . There is no risk at all because all the vaccines that are being used presently, none of them have the live virus in it. To fuse its viral membrane with the host cell membrane it substantially changes its shape from an unstable pre-fusion state to a stable post-fusion state. Save my name, email, and website in this browser for the next time I comment. It explains why nothing is releasedhttps://www.youtube.com/watch?v=9EfToFXwx98. IANS. concentrations of S1 (a subunit of spike) in 11 of 13 healthy vaccinated individuals and the full spike in 3 of 13, he said in an email, noting that the technology they used is 1,000 times more sensitive than a typical antigen test, so we are really detecting minute quantities of the spike and S1 proteins. (Emphasis is his). Bridle, Bryam. There is no damage when the spike protein is just inside a cell. Preprint Authors Kelly, Jeannie. McLellan, Jason. In elderly patients who are not already on deaths door, tolerance appears to be quite good (less, even, of flu-like symptoms post vaccination). Accessed 29 June 2021. The study concluded lactating individuals should continue breastfeeding after being vaccinated. a $230,000 grant from the Ontario government. In addition, the Food and Drug Administration inspects vaccine production facilities and reviews manufacturing protocols to make sure vaccine doses are of high-quality and free of contaminants. It is unlikely that enough of the spike protein could accumulate in breast milk to have any impact on infants that consume it, NIAID told us in a statement. My second instinct would be to blame any Fall/Winter surge in the UK and similarly here on variants. Regardless, studies have apparently found that the spike protein can cross the blood-brain barrier which is a giant red flag for the decision to target the spike protein for vaccine development on the assumption that it was a passive (harmless) target. See: https://www.npr.org/2021/02/09/965703047/vaccines-could-drive-the-evolution-of-more-covid-19-mutants. Each of those are thought to induce more than 2000 spike proteins in the cells they enter. . The most important message is that over 400 million doses of the mRNA vaccine have been administered with negligible serious consequences. Centers for Disease Control and Prevention. Bridle omits this information in his 37-page document, instead saying that detection of the mRNA was downplayed., Now we know the spike protein gets into circulation. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented. I wonder what this means for spike protein vaccine safety. COVID-19 spike protein damages blood vessels The "spike" proteins that the coronavirus uses to help it break into cells inflicts other damage as well, according to a new study that shines a. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circulation Research. Incredibly ignorant. So if I took a vaccine, those spike proteins would bypass the first layers of my immune system and will do their damage right in the core of my body. will target i) SARS-CoV-2 prevention by creating synthetic press@salk.edu. what is the half -life or the time scale the mRNA and the proteins will be floating around until mRNA is degraded and the spike proteins are met by the immune system? Spokesperson, Pfizer. Both the American College of Obstetricians and Gynecologists and the World Health Organization encourage women who are breastfeeding to take the vaccine. Member of the faculty at Harvard Medical School and of Harvards Wyss Institute for Biologically Inspired Engineering. The spike protein vaccine with the 2P mutation . Accessed 29 June 2021. This study links to an earlier one also sponsored by NIH suggesting that spike protein alone (introduced by vax)can trigger cell signaling and cell host damage e.g. All Rights Reserved. 2. your beta cells then process and read the enzyme with the mrna of the spike to watch out for the foot that will cause all this damage. Emails are serviced by Constant Contact. Vol. In fact, recent studies show breastfeeding after vaccinations may provide babies with protection. Newswise LA JOLLA-- (April 30, 2021) Scientists have known for a while that SARS-CoV-2's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. > Subscribe Free to Email Digest, UCLA astronomers think the object, X7, might be debris cloud from a stellar collision. The spike proteins from the virus and the ones generated by the vaccines are essentially the same, McLellan, the spike protein researcher at the University of Texas at Austin, told us, noting that they have the same function, structure and way of processing. Theres been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. The highest concentration of BNT162b2 mRNA in the tested samples was 2 ng/mL a hypothetical 0.667% of the original vaccine dose being transferred in 100 mL of human milk, the study says. My educated guess is this: Now that the vaccines are about to be used in kids as young as 12, I expect a more robust immune response and the presence of a better (faster) metabolism will translate into more immediate reports of adverse events among younger vaccine recipients the same group (with some exceptions!) Our conclusion was that the vaccine is working as intended.. National Institute of Allergy and Infectious Diseases. Safety of COVID-19 Vaccines. CDC.gov. The spike protein encoded by the mRNA vaccines (Moderna and Pfizer/BioNTech) and the J&J vaccine instruct the cells in our arm (where the injection is given) to produce spike protein that is tethered to the surface of the cell. and the World Health Organization encourage women who are breastfeeding to take the vaccine. If the mrna wiggles free from the enzyme that stabilizes the mrna vaccine, the immune system will just eradicate the mrna anyways. This gives your body the opportunity to learn how to fight it without the risk of the virus replicating so much that it does serious damage or kills you. The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xian Jiaotong University; and Xian Jiaotong University. No, thanks. How can you give the odds of someone dying of covid vs a vaccine like AstraZenica when you dont even know their medical history or current medications?
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